(2014) A chaperone boosts blood ??glucosidase activity in Pompe illness people taken care of with enzyme substitution therapy. Mol Thergene that encodes the lysosomal Ca2+?releasing channel TRPML1. Mucolipidosis IV pathology is the consequence of defective TRPML1 perform and aberrant Ca2+ signaling, and is characterized by impaired vesicle traffick